Wednesday, December 16, 2009

Does swine flu (H1N1) always show the clinical features?

Swine flu (H1N1) infection has clinical features like seasonal flu in it’s early stage. However, patients show the devastating symptoms at the progressive stage of viral pathogenesis inside the body. The neurological symptoms are shocking in the advanced stage. Recently, it is shown that some H1N1 patients have negative symptoms, revealing no clinical features all around it’s pathogenesis period. One report from Japanese high school students’ survey suggest that 20% of students and teachers infected with swine flu displayed no symptoms. Then, antibody testing confirmed the positive for H1N1 for those symptomless students. It is known that H1N1 flu possesses rapid replication capacity inside the body after primary pathogenesis; however, rapid multiplication might be one reason to show symptoms among some patients and/or it might be due to person to person physiological variations. The obvious mechanism is yet to be studied. Therefore, ‘clinical screening’ might be a good option for symptomless patients.

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